Standard Treatment Removal of the affected tube and ovary is generally all that is required since these tumors rarely occur in both ovaries.
Postoperative chemotherapy including cisplatin , bleomycin and etoposide is given to all patients for four courses with the exception of Grade 1 (well-differentiated) immature teratomas.
Vincristine , actinomycin-D and cyclophosphamide may be used in women who develop progressive disease.
Investigational
• Other combinations of chemotherapy, including carboplatin and ifosfamide , are currently under investigation.
Stages II, III and IV
Standard Treatment Depending on the extent and location of disease, a hysterectomy , bilateral removal of the tubes and ovaries, and aggressive tumor debulking . If the opposite ovary and uterus are normal, they can be preserved in women who want to maintain their reproductive function. Four courses of chemotherapy including cisplatin, bleomycin and etoposide are given after surgery.
Investigational
• Experimental therapy for advanced non-dysgerminomatous germ cell tumors include combinations of other
chemotherapeutic drugs such as carboplatin and ifosfamide.
